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Cynata Reports Breakthrough in GvHD Treatment

Cynata Therapeutics Limited (ASX: CYP), a clinical-stage biotechnology company pioneering cell therapies, has unveiled promising results from a Phase 1 clinical trial evaluating its lead product, CYP-001, for the treatment of steroid-resistant acute graft-versus-host disease (GvHD).

GvHD is a serious complication that can arise following allogeneic hematopoietic stem cell transplantation (HSCT), a potentially lifesaving treatment for blood cancers. HSCT involves transplanting stem cells from a matched donor into a patient. However, in some cases, the donor’s immune system attacks the recipient’s body, leading to GvHD. Steroid-resistant GvHD poses a significant challenge, as it often proves unresponsive to conventional treatment options.

CYP-001 is a mesenchymal stem cell (MSC) therapy derived from induced pluripotent stem cells (iPSCs). MSCs hold therapeutic potential due to their immunomodulatory properties, meaning they can regulate the immune system. Cynata’s Phase 1 trial investigated the safety and efficacy of CYP-001 in patients with steroid-resistant acute GvHD.

The trial enrolled 15 patients and evaluated the treatment’s safety and effectiveness over two years. The primary evaluation at Day 100 revealed positive results, with many patients achieving complete or overall response to the treatment. These initial findings were encouraging, and all participants continued the trial for a follow-up period to assess the long-term safety and efficacy of CYP-001.

The recently announced results encompass the two-year follow-up data. Overall, 60% of patients (9 out of 15) remained alive after two years, which compares favorably to previously published outcomes for patients with steroid-resistant acute GvHD treated with standard care. This data suggests that CYP-001 may offer a potential survival benefit for this patient population.

Importantly, no treatment-related serious adverse events or safety concerns were identified throughout the trial. This safety profile is crucial for any potential new therapy, particularly for a vulnerable patient population like those suffering from GvHD.

Cynata’s positive Phase 1 results represent a significant step forward in the development of CYP-001 as a treatment for steroid-resistant acute GvHD. The company plans to collaborate with its licensee, FUJIFILM, to design and launch further clinical trials to confirm these initial findings and explore the broader therapeutic potential of CYP-001.

The success of this therapy could offer new hope for patients with steroid-resistant GvHD, a currently difficult-to-treat condition with limited treatment options and poor prognoses. Further clinical trials will be pivotal in determining the long-term efficacy and safety of CYP-001, paving the way for its potential use in clinical practice.

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